Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

Lu, Yingchang, Vaarhorst, Anika, Merry, Audrey H H, Dollé, Martijn E T, Hovenier, Robert, Imholz, Sandra, Schouten, Leo J, Heijmans, Bastiaan T, Müller, Michael, Slagboom, P Eline, van den Brandt, Piet A, Gorgels, Anton P M, Boer, Jolanda M A and Feskens, Edith J M (2012) Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. PLoS One, 7 (7). ISSN 1932-6203

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Abstract

Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are markers of endogenous δ-5 and δ-6 desaturase activities, but have never been studied in relation to incident CHD. Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence.

Item Type: Article
Uncontrolled Keywords: adult,biological markers,cholesterol esters,cohort studies,coronary artery disease,fatty acid desaturases,fatty acids, unsaturated,female,genetic predisposition to disease,humans,incidence,male,middle aged,netherlands,polymorphism, single nucleotide,risk factors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 10 Jun 2014 20:40
Last Modified: 14 Sep 2020 07:03
URI: https://ueaeprints.uea.ac.uk/id/eprint/47646
DOI: 10.1371/journal.pone.0041681

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