Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development

Georgiadi, Anastasia, Wang, Yanan, Stienstra, Rinke, Tjeerdema, Nathanja, Janssen, Aafke, Stalenhoef, Anton, van der Vliet, J Adam, de Roos, Albert, Tamsma, Jouke T, Smit, Johannes W A, Tan, Nguan Soon, Müller, Michael, Rensen, Patrick C N and Kersten, Sander (2013) Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development. Arteriosclerosis, Thrombosis, and Vascular Biology, 33 (7). pp. 1529-1537. ISSN 1079-5642

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Abstract

Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development.

Item Type: Article
Uncontrolled Keywords: angiopoietins,animals,aorta,aortic diseases,apolipoprotein e3,atherosclerosis,carotid arteries,carotid stenosis,cell line,chemotaxis,cholesterol,diet, high-fat,disease models, animal,female,foam cells,humans,ligands,lipoproteins, ldl,macrophage activation,macrophages,magnetic resonance imaging,male,mice,mice, inbred c57bl,mice, transgenic,middle aged,time factors,toll-like receptor 3,toll-like receptor 4,triglycerides,up-regulation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 10 Jun 2014 20:30
Last Modified: 14 Sep 2020 07:03
URI: https://ueaeprints.uea.ac.uk/id/eprint/47636
DOI: 10.1161/ATVBAHA.113.301698

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