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Georgiadi, Anastasia, Wang, Yanan, Stienstra, Rinke, Tjeerdema, Nathanja, Janssen, Aafke, Stalenhoef, Anton, van der Vliet, J Adam, de Roos, Albert, Tamsma, Jouke T, Smit, Johannes W A, Tan, Nguan Soon, Müller, Michael 
ORCID: https://orcid.org/0000-0002-5930-9905, Rensen, Patrick C N and Kersten, Sander
(2013)
Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development.
Arteriosclerosis, Thrombosis, and Vascular Biology, 33 (7).
pp. 1529-1537.
ISSN 1079-5642
Abstract
Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | angiopoietins,animals,aorta,aortic diseases,apolipoprotein e3,atherosclerosis,carotid arteries,carotid stenosis,cell line,chemotaxis,cholesterol,diet, high-fat,disease models, animal,female,foam cells,humans,ligands,lipoproteins, ldl,macrophage activation,macrophages,magnetic resonance imaging,male,mice,mice, inbred c57bl,mice, transgenic,middle aged,time factors,toll-like receptor 3,toll-like receptor 4,triglycerides,up-regulation |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology |
| Depositing User: | Pure Connector |
| Date Deposited: | 10 Jun 2014 20:30 |
| Last Modified: | 24 Oct 2022 06:05 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/47636 |
| DOI: | 10.1161/ATVBAHA.113.301698 |
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