Hypothalamic food intake regulation in a cancer-cachectic mouse model

Dwarkasing, Jvalini T, van Dijk, Miriam, Dijk, Francina J, Boekschoten, Mark V, Faber, Joyce, Argilès, Josep M, Laviano, Alessandro, Müller, Michael ORCID: https://orcid.org/0000-0002-5930-9905, Witkamp, Renger F and van Norren, Klaske (2014) Hypothalamic food intake regulation in a cancer-cachectic mouse model. Journal of Cachexia, Sarcopenia and Muscle, 5 (2). pp. 159-169. ISSN 2190-5991

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Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still able to adapt adequately to changes in energy balance. Therefore, studying changes that occur on appetite regulators in the hypothalamus might reveal targets for treatment of cancer-induced eating disorders. By applying transcriptomics, many appetite-regulating systems in the hypothalamus could be taken into account, providing an overview of changes that occur in the hypothalamus during tumour growth.

Item Type: Article
Uncontrolled Keywords: cancer,hypothalamus,appetite,serotonin,transcriptomics,anorexia,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Depositing User: Pure Connector
Date Deposited: 12 Mar 2014 13:08
Last Modified: 24 Oct 2022 06:05
URI: https://ueaeprints.uea.ac.uk/id/eprint/47629
DOI: 10.1007/s13539-013-0121-y

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