A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats

Rendeiro, Catarina, Foley, Andrew, Lau, Vera C, Ring, Rebecca, Rodriguez-Mateos, Ana, Vauzour, David, Williams, Claire M, Regan, Ciaran and Spencer, Jeremy P E (2014) A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats. Neuropharmacology, 79. pp. 335-344. ISSN 0028-3908

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Abstract

The increase in incidence and prevalence of neurodegenerative diseases highlights the need for a more comprehensive understanding of how food components may affect neural systems. In particular, flavonoids have been recognized as promising agents capable of influencing different aspects of synaptic plasticity resulting in improvements in memory and learning in both animals and humans. Our previous studies highlight the efficacy of flavonoids in reversing memory impairments in aged rats, yet little is known about the effects of these compounds in healthy animals, particularly with respect to the molecular mechanisms by which flavonoids might alter the underlying synaptic modifications responsible for behavioral changes. We demonstrate that a 3-week intervention with two dietary doses of flavonoids (Dose I: 8.7 mg/day and Dose II: 17.4 mg/day) facilitates spatial memory acquisition and consolidation (24 recall) (p

Item Type: Article
Additional Information: Open Access under a Creative Commons Attribution 3.0 unported licence
Uncontrolled Keywords: bdnf; flavonoid; hippocampus; learning; memory; nmdr2b; psa-ncam
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 27 Jan 2014 13:58
Last Modified: 21 Apr 2020 22:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/47310
DOI: 10.1016/j.neuropharm.2013.12.003

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