The contribution of diet and genotype to iron status in women:a classical twin study

Fairweather-Tait, Susan J ORCID: https://orcid.org/0000-0002-1413-5569, Guile, Geoffrey R, Valdes, Ana M, Wawer, Anna A, Hurst, Rachel, Skinner, Jane and Macgregor, Alexander J ORCID: https://orcid.org/0000-0003-2163-2325 (2013) The contribution of diet and genotype to iron status in women:a classical twin study. PLoS One, 8 (12). ISSN 1932-6203

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Abstract

This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in determining iron status. The population was comprised of 200 BMI- and age-matched pairs of MZ and DZ healthy twins, characterised for habitual diet and 15 iron-related candidate genetic markers. Variance components analysis demonstrated that the heritability of serum ferritin (SF) and soluble transferrin receptor was 44% and 54% respectively. Measured single nucleotide polymorphisms explained 5% and selected dietary factors 6% of the variance in iron status; there was a negative association between calcium intake and body iron (p = 0.02) and SF (p = 0.04).

Item Type:	Article
Additional Information:	© 2013 Fairweather-Tait et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The research was supported by the Wellcome Trust. Anna Wawer is funded by a BBSRC-CASE studentship [BB/G53015X]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The data are available on application from the Twin Unit.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	27 Jan 2014 14:00
Last Modified:	19 Oct 2023 01:16
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47216
DOI:	10.1371/journal.pone.0083047

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