Challenges in the development of heteromer-GPCR-based drugs

Franco, Rafael, Martínez-Pinilla, Eva, Ricobaraza, Ana and McCormick, Peter J. (2013) Challenges in the development of heteromer-GPCR-based drugs. In: Progress in Molecular Biology and Translational Science. UNSPECIFIED, pp. 143-162. ISBN 9780123869319

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Abstract

G-protein-coupled receptors are targets of a variety of diseases. Drug screening has been classically performed assuming the occurrence of monomeric receptors. As more and more receptor heteromers are identified, the challenge is now to develop screening assays to select heteromer-specific drugs. These drugs may, for instance, be able to interact preferentially with prerather than with postsynaptic receptors. Heteromer-based drug discovery opens new perspectives in both Academic pursuits and for the Pharmaceutical industry.

Item Type: Book Section
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: Pure Connector
Date Deposited: 13 Jan 2014 13:44
Last Modified: 28 Apr 2020 00:11
URI: https://ueaeprints.uea.ac.uk/id/eprint/47168
DOI: 10.1016/B978-0-12-386931-9.00006-4

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