WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism

Sherwood, Victoria, Chaurasiya, Shivendra Kumar, Ekström, Elin J, Guilmain, William, Liu, Qing, Koeck, Thomas, Brown, Kate, Hansson, Karin, Agnarsdóttir, Margrét, Bergqvist, Michael, Jirström, Karin, Ponten, Fredrik, James, Peter and Andersson, Tommy (2014) WNT5A-Mediated β-Catenin-Independent Signalling is a Novel Regulator of Cancer Cell Metabolism. Carcinogenesis, 35 (4). pp. 784-794. ISSN 0143-3334

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Abstract

WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand(')s role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin (CTNNB1)-independent WNT signalling in oncology. Here we report that one of the initial effects of active WNT5A signalling in malignant melanoma cells is an alteration in cellular energy metabolism and specifically an increase in aerobic glycolysis. This was found to be at least in part due to an increase in active Akt signalling and lactate dehydrogenase (LDH) activity. The clinical relevance of these findings was strengthened by a strong correlation (p

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 14:42
Last Modified: 24 Jul 2019 19:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/47093
DOI: 10.1093/carcin/bgt390

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