Vascular and Inflammatory High Fat Meal Responses in Young Healthy Men; A Discriminative Role of IL-8 Observed in a Randomized Trial

Esser, Diederik, Oosterink, Els, op 't Roodt, Jos, Henry, Ronald M. A., Stehouwer, Coen D. A., Müller, Michael and Afman, Lydia A. (2013) Vascular and Inflammatory High Fat Meal Responses in Young Healthy Men; A Discriminative Role of IL-8 Observed in a Randomized Trial. PLoS One, 8 (2). ISSN 1932-6203

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Abstract

Background: High fat meal challenges are known to induce postprandial low-grade inflammation and endothelial dysfunction. This assumption is largely based on studies performed in older populations or in populations with a progressed disease state and an appropriate control meal is often lacking. Young healthy individuals might be more resilient to such challenges. We therefore aimed to characterize the vascular and inflammatory response after a high fat meal in young healthy individuals. Methods: In a double-blind randomized cross-over intervention study, we used a comprehensive phenotyping approach to determine the vascular and inflammatory response after consumption of a high fat shake and after an average breakfast shake in 20 young healthy subjects. Both interventions were performed three times. Results: Many features of the vascular postprandial response, such as FMD, arterial stiffness and micro-vascular skin blood flow were not different between shakes. High fat/high energy shake consumption was associated with a more pronounced increase in blood pressure, heart rate, plasma concentrations of IL-8 and PBMCs gene expression of IL-8 and CD54 (ICAM-1), whereas plasma concentrations of sVCAM1 were decreased compared to an average breakfast. Conclusion: Whereas no difference in postprandial response were observed on classical markers of endothelial function, we did observe differences between consumption of a HF/HE and an average breakfast meal on blood pressure and IL-8 in young healthy volunteers. IL-8 might play an important role in dealing with high fat challenges and might be an early marker for endothelial stress, a stage preceding endothelial dysfunction. Trial Registration: ClinicalTrials.gov NCT00766623.

Item Type: Article
Additional Information: © 2013 Esser et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords: adult,blood pressure,cross-over studies,diet, high-fat,dietary fats,double-blind method,gene expression,heart rate,humans,inflammation,intercellular adhesion molecule-1,interleukin-8,male,meals,postprandial period,regional blood flow,skin,vascular stiffness,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 18 Dec 2013 12:18
Last Modified: 14 Sep 2020 07:02
URI: https://ueaeprints.uea.ac.uk/id/eprint/47057
DOI: 10.1371/journal.pone.0053474

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