Phenotyping the effect of diet on non-alcoholic fatty liver disease

De Wit, N.J.W., Afman, L.A., Mensink, M. and Müller, M. ORCID: (2012) Phenotyping the effect of diet on non-alcoholic fatty liver disease. Journal of Hepatology, 57 (6). pp. 1370-1373. ISSN 0168-8278

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Non-alcoholic fatty liver disease (NAFLD) is associated with the growing incidence of metabolic syndrome. Diet is an important contributor to the pathogenesis of NAFLD. In this review, we focused on recent publications reporting on the effect of macro- and micronutrients on development and progression of NAFLD. In general, saturated fat and fructose seem to stimulate hepatic lipid accumulation and progression into NASH, whereas unsaturated fat, choline, antioxidants, and high-protein diets rich in isoflavones seem to have a more preventive effect. Knowledge of the underlying mechanisms by which diet affects NAFLD is expanding, not in the least due to innovative techniques, such as genomics tools that provide detailed comprehensive information on a large high-throughput scale. Although most nutrients seem to interfere with the balance between hepatic de novo lipogenesis (endogenous synthesis of fatty acids) and lipid oxidation (burning fat for energy), there are also indications that diet can trigger or prevent hepatic lipid accumulation by influencing the interaction between liver, gut, and adipose tissue. This review now gives a current detailed overview of diet-mediated mechanisms underlying NAFLD development and progression and summarizes recent results of genomics (transcriptomics, proteomics and metabolomics) studies that contribute to improved staging, monitoring and understanding of NAFLD pathophysiology.

Item Type: Article
Additional Information: Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Uncontrolled Keywords: diet,dietary carbohydrates,dietary fats,dietary proteins,fatty liver,humans,metabolomics,phenotype,proteomics,transcriptome
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
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Depositing User: Pure Connector
Date Deposited: 18 Dec 2013 12:12
Last Modified: 24 Oct 2022 05:54
DOI: 10.1016/j.jhep.2012.07.003

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