Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2

Hockley, Sarah L, Arlt, Volker M, Brewer, Daniel ORCID: https://orcid.org/0000-0003-4753-9794, Giddings, Ian and Phillips, David H (2006) Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2. BMC Genomics, 7. ISSN 1471-2164

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Abstract

The multi-step process of carcinogenesis can be more fully understood by characterizing gene expression changes induced in cells by carcinogens. In this study, expression microarrays were used to monitor the activity of 18,224 cDNA clones in MCF-7 and HepG2 cells exposed to the carcinogen benzo(a)pyrene (BaP) or its non-carcinogenic isomer benzo(e)pyrene (BeP). Time and concentration gene expression effects of BaP exposure have been assessed and linked to other measures of cellular stress to aid in the identification of novel genes/pathways involved in the cellular response to genotoxic carcinogens.

Item Type:	Article
Uncontrolled Keywords:	benzo(a)pyrene,cell cycle,cell line,cell survival,dna adducts,gene expression,gene expression profiling,humans,principal component analysis,reverse transcriptase polymerase chain reaction,time factors,tumor suppressor protein p53
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2014 14:18
Last Modified:	19 Oct 2023 01:15
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47045
DOI:	10.1186/1471-2164-7-260

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