Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

Reid, A H M, Attard, G, Ambroisine, L, Fisher, G, Kovacs, G, Brewer, D, Clark, J, Flohr, P, Edwards, S, Berney, D M, Foster, C S, Fletcher, A, Gerald, W L, Møller, H, Reuter, V E, Scardino, P T, Cuzick, J, de Bono, J S, Cooper, C S and , Transatlantic Prostate Group (2010) Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. British Journal of Cancer, 102 (4). pp. 678-684. ISSN 0007-0920

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Abstract

The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status.

Item Type: Article
Uncontrolled Keywords: aged,carcinoma,cause of death,cohort studies,dna mutational analysis,dna-binding proteins,genetic loci,humans,in situ hybridization, fluorescence,male,middle aged,models, biological,pten phosphohydrolase,prognosis,prostatic neoplasms,retrospective studies,risk factors,survival analysis,tissue array analysis,trans-activators,transcription factors
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 14:16
Last Modified: 21 Apr 2020 22:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/47030
DOI: 10.1038/sj.bjc.6605554

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