Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives

Wyatt, Paul G., Allen, Michael J., Chilcott, Josie, Gardner, Christopher J., Livermore, David G. ORCID: https://orcid.org/0000-0002-9856-3703, Mordaunt, Jackie E., Nerozzi, Fabrizio, Patel, Mamta, Perren, Marion J., Weingarten, Gordon G., Shabbir, Shalia, Woollard, Patrick M. and Zhou, Ping (2002) Identification of potent and selective oxytocin antagonists. Part 2: Further investigation of benzofuran derivatives. Bioorganic & Medicinal Chemistry Letters, 12 (10). pp. 1405-1411. ISSN 0960-894X

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Abstract

The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.

Item Type:	Article
Uncontrolled Keywords:	animals,benzofurans,drug design,female,humans,kinetics,models, molecular,molecular conformation,oxytocin,rats,receptors, oxytocin,structure-activity relationship,uterine contraction
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Depositing User:	Pure Connector
Date Deposited:	24 Jan 2014 12:40
Last Modified:	14 Aug 2023 11:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46758
DOI:	10.1016/S0960-894X(02)00160-9

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