In vitro activity of a novel oxazolidinone, AZD2563, against randomly selected and multiresistant Gram-positive cocci

Johnson, Alan P, Warner, Marina and Livermore, David M (2002) In vitro activity of a novel oxazolidinone, AZD2563, against randomly selected and multiresistant Gram-positive cocci. Journal of Antimicrobial Chemotherapy, 50 (1). pp. 89-93. ISSN 0305-7453

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Abstract

The in vitro activity of AZD2563, a novel oxazolidinone, was assessed against 595 Gram-positive cocci, comprising recent surveillance isolates and a collection of resistant (including multiresistant), epidemiologically diverse isolates. The MICs of AZD2563 for staphylococci, pneumococci and enterococci had narrow ranges, 0.25-2 mg/L, with modal MICs of 1 mg/L for staphylococci and pneumococci, and 1-2 mg/L for enterococci. AZD2563 was equally active against the surveillance isolates and those that had been selected for their multiresistance to other agents. The MICs of AZD2563 were either the same as those of linezolid or two-fold lower.

Item Type: Article
Uncontrolled Keywords: acetamides,anti-bacterial agents,coagulase,drug resistance, multiple, bacterial,enterococcus faecalis,enterococcus faecium,gram-positive cocci,humans,microbial sensitivity tests,oxazolidinones,staphylococcus aureus,streptococcus pneumoniae
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Jan 2014 12:38
Last Modified: 21 Apr 2020 22:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/46755
DOI:

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