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Livermore, David M 
ORCID: https://orcid.org/0000-0002-9856-3703
(2009)
beta-Lactamases- the Threat Renews.
Current Protein and Peptide Science, 10 (5).
pp. 397-400.
ISSN 1875-5550
Abstract
Beta-lactamases are the greatest single source of resistance to beta-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new beta-lactam analogues are introduced but then select for new beta-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM-1 enzyme and modern oxymino cephalosporins by "extended-spectrum" beta-lactamases. Tony Fink's work contributed greatly to our understanding of the mechanisms and active site function of beta-lactamases and this knowledge now informs the search for new beta-lactams and beta-lactamase inhibitors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | bacterial infections,drug design,drug resistance, bacterial,escherichia coli,humans,microbial sensitivity tests,models, chemical,penicillins,staphylococcus aureus,world health,beta-lactamases,beta-lactams |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Depositing User: | Pure Connector |
| Date Deposited: | 06 Jan 2014 15:26 |
| Last Modified: | 24 Oct 2022 05:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/46693 |
| DOI: |
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