beta-Lactamases- the Threat Renews

Livermore, David M ORCID: (2009) beta-Lactamases- the Threat Renews. Current Protein and Peptide Science, 10 (5). pp. 397-400. ISSN 1875-5550

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Beta-lactamases are the greatest single source of resistance to beta-lactam antibiotics. For over 60 years, clinicians have seen a pattern whereby useful new beta-lactam analogues are introduced but then select for new beta-lactamases that cause resistance. Thus, penicillin G was undermined by swift accumulation of staphylococcal penicillinase, ampicillin by TEM-1 enzyme and modern oxymino cephalosporins by "extended-spectrum" beta-lactamases. Tony Fink's work contributed greatly to our understanding of the mechanisms and active site function of beta-lactamases and this knowledge now informs the search for new beta-lactams and beta-lactamase inhibitors.

Item Type: Article
Uncontrolled Keywords: bacterial infections,drug design,drug resistance, bacterial,escherichia coli,humans,microbial sensitivity tests,models, chemical,penicillins,staphylococcus aureus,world health,beta-lactamases,beta-lactams
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 15:26
Last Modified: 24 Oct 2022 05:45

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