The emerging NDM carbapenemases

Nordmann, Patrice, Poirel, Laurent, Walsh, Timothy R and Livermore, David M (2011) The emerging NDM carbapenemases. Trends in Microbiology, 19 (12). pp. 588-95. ISSN 0966-842X

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Abstract

Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian subcontinent, where they occur widely in hospital and community infections, and also in contaminated urban water. The main type is NDM-1, but minor variants occur. NDM enzymes are present largely in Enterobacteriaceae, but also in non-fermenters and Vibrionaceae. Dissemination predominantly involves transfer of the blaNDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resistant to nearly all antibiotics, and reliable detection and surveillance are crucial.

Item Type: Article
Additional Information: Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
Uncontrolled Keywords: bacterial proteins,carbapenems,disease outbreaks,enterobacteriaceae,gene transfer, horizontal,gram-negative bacterial infections,humans,plasmids,pseudomonas,vibrionaceae,beta-lactam resistance,beta-lactamases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 20 Jan 2014 16:54
Last Modified: 21 Apr 2020 22:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/46663
DOI: 10.1016/j.tim.2011.09.005

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