Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom

Giske, Christian G, Fröding, Inga, Hasan, Chowdhury Mehedi, Turlej-Rogacka, Agata, Toleman, Mark, Livermore, David, Woodford, Neil and Walsh, Timothy R (2012) Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrobial Agents and Chemotherapy, 56 (5). pp. 2735-8. ISSN 0066-4804

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Abstract

Clinical isolates of Klebsiella pneumoniae producing NDM-1 carbapenemase from India (n = 22), the United Kingdom (n = 13), and Sweden (n = 4) were subjected to multilocus sequence typing (MLST), automated repetitive sequence-based PCR (rep-PCR), serotyping, virulence gene screening, and plasmid replicon typing. The most frequently detected MLST sequence types (STs) were ST14 (n = 13; all serotype K2), ST11, ST149, ST231, and ST147. The correlation between MLST and automated rep-PCR was excellent. IncA/C was the most frequently detected plasmid replicon type (n = 14). ST14, ST11, and other successful clones may be important for the dissemination of bla(NDM-1).

Item Type: Article
Uncontrolled Keywords: electrophoresis, gel, pulsed-field,gene transfer, horizontal,great britain,humans,india,klebsiella pneumoniae,multilocus sequence typing,phylogeography,plasmids,polymerase chain reaction,replicon,serotyping,sweden,beta-lactam resistance,beta-lactamases
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 20 Jan 2014 16:54
Last Modified: 21 Apr 2020 22:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/46662
DOI: 10.1128/AAC.06142-11

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