Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors

Kwok, Chun Shing and Loke, Yoon Kong (2012) Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors. Expert Opinion on Drug Safety, 11 (2). pp. 275-84. ISSN 1744-764X

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Abstract

There is considerable debate surrounding the clinical relevance of an adverse interaction between clopidogrel and proton pump inhibitors (PPIs). Some studies have indicated that PPIs may attenuate the antiplatelet efficacy of clopidogrel, thus leading to increased risk of thrombotic cardiovascular events.

Item Type: Article
Uncontrolled Keywords: animals,blood platelets,drug interactions,evidence-based medicine,gastrointestinal hemorrhage,humans,platelet aggregation inhibitors,proton pump inhibitors,risk assessment,risk factors,ticlopidine
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 20 Jan 2014 16:48
Last Modified: 21 Apr 2020 22:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/46604
DOI: 10.1517/14740338.2012.657175

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