Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis

Jennings, Barbara Anne, Kwok, Chun Shing, Willis, Gavin, Matthews, Victoria, Wawruch, Pawel and Loke, Yoon Kong (2012) Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis. Pharmacogenetics and Genomics, 22 (4). pp. 290-304. ISSN 1744-6880

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Abstract

Many primary studies have considered the association of polymorphisms of folate metabolism and response to 5-fluorouracil (5-FU) and capecitabine in patients with colorectal cancer. The conclusions from these studies have been conflicting and few have considered large cohorts of patients. Therefore, we have completed a systematic review and meta-analyses to summarize some of the findings to date. We conducted searches for any studies that had addressed the prognostic value of genotype analysis of thymidylate synthetase (TYMS), Methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR).

Item Type:	Article
Uncontrolled Keywords:	colorectal neoplasms,databases, genetic,deoxycytidine,fluorouracil,folic acid,gene expression regulation, neoplastic,genetic association studies,genetic variation,genotype,humans,methylenetetrahydrofolate reductase (nadph2),tetrahydrofolate dehydrogenase,thymidylate synthase,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	20 Jan 2014 16:48
Last Modified:	28 Mar 2025 05:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46602
DOI:	10.1097/FPC.0b013e328351875d

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