Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

Clark, Jeremy J, Sandberg, Stefan G, Wanat, Matthew J, Gan, Jerylin O, Horne, Eric A, Hart, Andrew S, Akers, Christina A, Parker, Jones G, Willuhn, Ingo, Martinez, Vicente, Evans, Scott B, Stella, Nephi and Phillips, Paul E M (2010) Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals. Nature Methods, 7 (2). pp. 126-9. ISSN 1548-7105

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Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.

Item Type: Article
Uncontrolled Keywords: animals,behavior, animal,biosensing techniques,dopamine,electrochemistry,electrodes, implanted,equipment design,equipment failure analysis,mesencephalon,mice,microelectrodes,miniaturization,monitoring, ambulatory,neurotransmitter agents,rats,reproducibility of results,sensitivity and specificity
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 14:12
Last Modified: 24 Oct 2022 05:40
DOI: 10.1038/nmeth.1412

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