Unexpected syncope and death during intense physical training:evolving role of molecular genetics

Fox, Chris ORCID: https://orcid.org/0000-0001-9480-5704 and Lockette, Warren (2003) Unexpected syncope and death during intense physical training:evolving role of molecular genetics. Aviation, Space, and Environmental Medicine, 74 (12). pp. 1223-30. ISSN 0095-6562

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Special operations forces (SOF) undergo an unparalleled degree of physical training. The medical officer responsible for these personnel must often deal with episodes of syncope that cannot be readily explained. In the past, loss of consciousness during heavy physical exertion was attributed to inadequate fluid intake resulting in dehydration or abnormalities in temperature regulation. However, many of those diagnoses, in retrospect were probably incorrect. The occurrence of exercise-related syncope in multiple members of the same family suggested that there could be a genetic basis for the unexpected loss of consciousness during exercise. Intensive clinical examinations of these patients, coupled with current advances in molecular genetics, have shown this to be the case. We review some of the more common genetic abnormalities associated with exertion-related syncope. These syndromes should be considered by the medical officer presented with a patient having syncope of indeterminate cause.

Item Type: Article
Uncontrolled Keywords: cardiomyopathy, hypertrophic,death, sudden,exercise,genetic predisposition to disease,humans,long qt syndrome,malignant hyperthermia,military personnel,pedigree,syncope
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 20 Jan 2014 16:18
Last Modified: 24 Oct 2022 05:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/46344

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