Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling

Watson, Oliver, Novodvorsky, Peter, Gray, Caroline, Rothman, Alexander M K, Lawrie, Allan, Crossman, David C, Haase, Andrea, McMahon, Kathryn, Gering, Martin, Van Eeden, Fredericus J M and Chico, Timothy J A (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling. Cardiovascular Research, 100 (2). pp. 252-61. ISSN 0008-6363

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Abstract

The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-regulated hypoxic signalling.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 15:26
Last Modified: 21 Apr 2020 22:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/46173
DOI: 10.1093/cvr/cvt170

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