Multiple loci on 8q24 associated with prostate cancer susceptibility

Al Olama, Ali Amin, Kote-Jarai, Zsofia, Giles, Graham G, Guy, Michelle, Morrison, Jonathan, Severi, Gianluca, Leongamornlert, Daniel A, Tymrakiewicz, Malgorzata, Jhavar, Sameer, Saunders, Ed, Hopper, John L, Southey, Melissa C, Muir, Kenneth R, English, Dallas R, Dearnaley, David P, Ardern-Jones, Audrey T, Hall, Amanda L, O'Brien, Lynne T, Wilkinson, Rosemary A, Sawyer, Emma, Lophatananon, Artitaya, Horwich, Alan, Huddart, Robert A, Khoo, Vincent S, Parker, Christopher C, Woodhouse, Christopher J, Thompson, Alan, Christmas, Tim, Ogden, Chris, Cooper, Colin, Donovan, Jenny L, Hamdy, Freddie C, Neal, David E, Eeles, Rosalind A, Easton, Douglas F and , UK Genetic Prostate Cancer Study Collaborators/British Associati (2009) Multiple loci on 8q24 associated with prostate cancer susceptibility. Nature Genetics, 41 (10). pp. 1058-60. ISSN 1061-4036

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Abstract

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

Item Type: Article
Uncontrolled Keywords: chromosomes, human, pair 8,disease susceptibility,genome, human,genome-wide association study,genotype,humans,male,polymorphism, single nucleotide,prostatic neoplasms,risk factors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 20 Jan 2014 16:00
Last Modified: 07 Jul 2020 23:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/46140
DOI: 10.1038/ng.452

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