Multiple loci on 8q24 associated with prostate cancer susceptibility

Al Olama, Ali Amin, Kote-Jarai, Zsofia, Giles, Graham G, Guy, Michelle, Morrison, Jonathan, Severi, Gianluca, Leongamornlert, Daniel A, Tymrakiewicz, Malgorzata, Jhavar, Sameer, Saunders, Ed, Hopper, John L, Southey, Melissa C, Muir, Kenneth R, English, Dallas R, Dearnaley, David P, Ardern-Jones, Audrey T, Hall, Amanda L, O'Brien, Lynne T, Wilkinson, Rosemary A, Sawyer, Emma, Lophatananon, Artitaya, Horwich, Alan, Huddart, Robert A, Khoo, Vincent S, Parker, Christopher C, Woodhouse, Christopher J, Thompson, Alan, Christmas, Tim, Ogden, Chris, Cooper, Colin ORCID:, Donovan, Jenny L, Hamdy, Freddie C, Neal, David E, Eeles, Rosalind A and Easton, Douglas F and UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology (2009) Multiple loci on 8q24 associated with prostate cancer susceptibility. Nature Genetics, 41 (10). pp. 1058-60. ISSN 1061-4036

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Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

Item Type: Article
Uncontrolled Keywords: chromosomes, human, pair 8,disease susceptibility,genome, human,genome-wide association study,genotype,humans,male,polymorphism, single nucleotide,prostatic neoplasms,risk factors,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User: Pure Connector
Date Deposited: 20 Jan 2014 16:00
Last Modified: 03 Nov 2022 15:34
DOI: 10.1038/ng.452

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