The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine

Whitaker, Hayley C, Kote-Jarai, Zsofia, Ross-Adams, Helen, Warren, Anne Y, Burge, Johanna, George, Anne, Bancroft, Elizabeth, Jhavar, Sameer, Leongamornlert, Daniel, Tymrakiewicz, Malgorzata, Saunders, Edward, Page, Elizabeth, Mitra, Anita, Mitchell, Gillian, Lindeman, Geoffrey J, Evans, D Gareth, Blanco, Ignacio, Mercer, Catherine, Rubinstein, Wendy S, Clowes, Virginia, Douglas, Fiona, Hodgson, Shirley, Walker, Lisa, Donaldson, Alan, Izatt, Louise, Dorkins, Huw, Male, Alison, Tucker, Kathy, Stapleton, Alan, Lam, Jimmy, Kirk, Judy, Lilja, Hans, Easton, Douglas, Cooper, Colin, Eeles, Rosalind, Neal, David E and , IMPACT Study Steering Committee (2010) The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. PLoS One, 5 (10). ISSN 1932-6203

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Abstract

Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.

Item Type: Article
Uncontrolled Keywords: alleles,enzyme-linked immunosorbent assay,genetic predisposition to disease,genotype,humans,immunohistochemistry,male,prostate-specific antigen,prostatic neoplasms,prostatic secretory proteins,tumor markers, biological
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 11 Jun 2014 12:52
Last Modified: 21 Apr 2020 22:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/46127
DOI: 10.1371/journal.pone.0013363

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