Active modification of host inflammation by Salmonella

Pilar, Ana Victoria C, Reid-Yu, Sarah A, Cooper, Colin A ORCID:, Mulder, David T and Coombes, Brian K (2013) Active modification of host inflammation by Salmonella. Gut Microbes, 4 (2). pp. 140-5. ISSN 1949-0976

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The dampening of host immune responses is a critical aspect of pathogenesis for the enteropathogen Salmonella enterica. Our laboratory has recently described a role for the secreted effector GogB in disruption of NFκB activation and limitation of the host inflammatory response to infection. GogB alters the NFκB pathway by preventing IκB degradation by the host SCF E3 ubiquitin ligase, through an interaction with Skp1 and FBXO22. The prevention of NFκB activation through this interaction dampens the host inflammatory response in the gut, which in turn limits the damage to host tissues during chronic infection. In this addendum, we summarize these recent findings and discuss their implications and impact in the area of host-pathogen interactions.

Item Type: Article
Uncontrolled Keywords: animals,bacterial proteins,disease models, animal,f-box proteins,gastroenteritis,host-pathogen interactions,humans,i-kappa b proteins,immune evasion,models, biological,nf-kappa b,s-phase kinase-associated proteins,skp cullin f-box protein ligases,salmonella infections, animal,salmonella enterica,virulence factors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 15:02
Last Modified: 24 Oct 2022 05:30
DOI: 10.4161/gmic.23361

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