Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system

Meader, Emma, Mayer, Melinda J, Steverding, Dietmar, Carding, Simon R and Narbad, Arjan (2013) Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an in vitro human colon model system. Anaerobe, 22. pp. 25-30. ISSN 1095-8274

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Abstract

Clostridium difficile is a leading cause of hospital-acquired diarrhoea and represents a major challenge for healthcare providers. Due to the decreasing efficacy and associated problems of antibiotic therapy there is a need for synergistic and alternative treatments. In this study we investigated the use of a specific bacteriophage, ΦCD27, in a human colon model of C. difficile infection. Our findings demonstrate a significant reduction in the burden of C. difficile cells and toxin production with phage treatment relative to an untreated control, with no detrimental effect on commensal bacterial populations. The results demonstrate the potential of phage therapy, and highlight the limitations of using phages that have lysogenic capacity.

Item Type: Article
Additional Information: Copyright © 2013 Elsevier Ltd. All rights reserved.
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 06 Jan 2014 14:12
Last Modified: 21 Apr 2020 22:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/45988
DOI: 10.1016/j.anaerobe.2013.05.001

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