Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man

Kumari, Veena, Gray, Jeffrey A., Corr, Philip J., Mulligan, Owen F., Cotter, Paul A. and Checkley, Stuart A. (1997) Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man. Psychopharmacology, 129 (3). pp. 271-276. ISSN 0033-3158

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Abstract

The effects of an indirect dopamine-agonist, d-amphetamine, and a non-selective dopamine receptor antagonist, haloperidol, were investigated in normal male volunteers using a between-subjects double-blind design in a procedural learning task, thought mainly to involve unconscious/automatic learning. The results showed: (1) d-amphetamine facilitated response speed, whereas haloperidol inhibited it, in comparison to placebo; (2) the linear increase in procedural learning corresponded with pharmacological manipulation of degree of dopaminergic activity, i.e. subjects given haloperidol showed the least, and subjects given d-amphetamine the greatest, procedural learning. The implications of these findings are discussed in relation to investigation of abnormalities of procedural learning processes in schizophrenia.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,dextroamphetamine,dopamine agonists,dopamine antagonists,haloperidol,humans,learning,male,middle aged
Faculty \ School:	Faculty of Social Sciences > School of Psychology
Depositing User:	Pure Connector
Date Deposited:	05 Feb 2014 13:38
Last Modified:	26 Sep 2022 06:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/45833
DOI:	10.1007/s002130050190

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