Kumari, Veena, Gray, Jeffrey A., Corr, Philip J., Mulligan, Owen F., Cotter, Paul A. and Checkley, Stuart A. (1997) Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man. Psychopharmacology, 129 (3). pp. 271-276. ISSN 0033-3158

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Abstract

The effects of an indirect dopamine-agonist, d-amphetamine, and a non-selective dopamine receptor antagonist, haloperidol, were investigated in normal male volunteers using a between-subjects double-blind design in a procedural learning task, thought mainly to involve unconscious/automatic learning. The results showed: (1) d-amphetamine facilitated response speed, whereas haloperidol inhibited it, in comparison to placebo; (2) the linear increase in procedural learning corresponded with pharmacological manipulation of degree of dopaminergic activity, i.e. subjects given haloperidol showed the least, and subjects given d-amphetamine the greatest, procedural learning. The implications of these findings are discussed in relation to investigation of abnormalities of procedural learning processes in schizophrenia.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,dextroamphetamine,dopamine agonists,dopamine antagonists,haloperidol,humans,learning,male,middle aged
Faculty \ School:	Faculty of Social Sciences > School of Psychology
Depositing User:	Pure Connector
Date Deposited:	05 Feb 2014 13:38
Last Modified:	11 Nov 2019 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/45833
DOI:	10.1007/s002130050190

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