The potential application of ribozymes for the treatment of hematological disorders

James, H A (1999) The potential application of ribozymes for the treatment of hematological disorders. Journal of Leukocyte Biology, 66 (3). pp. 361-368. ISSN 0741-5400

Full text not available from this repository. (Request a copy)

Abstract

With the identification and increasing understanding of the genes involved in neoplastic transformation has come the realization that abrogation of these genes' products may lead to cell death or a return to normalcy. The use of ribozymes and their nucleic acid cousins, antisense oligodeoxynucleotides (ODNs), are two such ways of perturbing the disease-related gene expression. This review will look at the development and application of ribozymes to abrogate gene expression, with particular relevance to hematological settings. Some examples of antisense ODNs will also be mentioned where appropriate.

Item Type: Article
Uncontrolled Keywords: drug resistance, neoplasm,gene expression regulation,genetic therapy,hematologic diseases,hematologic neoplasms,humans,immune system diseases,nucleic acid conformation,oligonucleotides, antisense,oncogene proteins, fusion,oncogenes,rna, catalytic,virus diseases,virus replication
Faculty \ School: Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 27 Nov 2013 13:20
Last Modified: 21 Apr 2020 22:19
URI: https://ueaeprints.uea.ac.uk/id/eprint/45037
DOI:

Actions (login required)

View Item View Item