Inflammation and frailty measures in older people

Hubbard, Ruth E, O'Mahony, M Sinead, Savva, George M, Calver, Brian L and Woodhouse, Ken W (2009) Inflammation and frailty measures in older people. Journal of Cellular and Molecular Medicine, 13 (9B). pp. 3103-3109. ISSN 1582-4934

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Inflammation in patients defined as frail by Fried's phenotypic definition may be related to sarcopenia. This study aimed to investigate inflammation in older patients across different frailty criteria. Frailty status was determined in 110 patients aged over 75 years (mean 83.9 years) according to function (dependent, intermediate, independent); Fried (three or more items of exhaustion, weight loss, slow walking speed, low handgrip strength, low physical activity) and Frailty Index (a measure of accumulated deficits). With increasing patient frailty as defined by function and by Fried phenotype, tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP) increased significantly. Albumin was lowest in the frailest subjects by each definition. The greatest differences were seen between intermediate and dependent groups and between the pre-frail and frail. Adjustment for multiple covariates (age, sex, BMI category, smoking status, number of co-morbidities and number of prescribed medications) did not account for any of the observed differences in levels of inflammatory markers. The Frailty Index correlated significantly with log-transformed CRP (r= 0.221, P

Item Type: Article
Uncontrolled Keywords: aged,aged, 80 and over,albumins,body mass index,c-reactive protein,comorbidity,female,frail elderly,humans,inflammation,interleukin-6,male,phenotype,smoking,tumor necrosis factor-alpha
Faculty \ School:
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Health in Later Life (former - to 2017)
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User: Pure Connector
Date Deposited: 02 Dec 2013 14:32
Last Modified: 04 Dec 2023 01:38
DOI: 10.1111/j.1582-4934.2009.00733.x

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