Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

Nicoll, J A R, Savva, G M, Stewart, J, Matthews, F E, Brayne, C, Ince, P and , Medical Research Council Cognitive Function and Ageing Study (2011) Association between APOE genotype, neuropathology and dementia in the older population of England and Wales. Neuropathology and Applied Neurobiology, 37 (3). pp. 285-294. ISSN 1365-2990

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Abstract

Apolipoprotein E (APOE) genotype is the major genetic risk factor for sporadic Alzheimer's disease (AD) but it is unclear how this is mediated. Most studies of APOE genotype have used case-control design to compare groups differing by two variables: i.e. dementia and AD pathology, so it is unclear to which of these variables APOE genotype is more strongly related. The prospective Medical Research Council Cognitive Function and Ageing Study neuropathology cohort is population-based sample in which donations are unbiased by dementia status.

Item Type: Article
Additional Information: © 2011 The Authors. Neuropathology and Applied Neurobiology © 2011 British Neuropathological Society.
Uncontrolled Keywords: aged,aged, 80 and over,alzheimer disease,apolipoproteins e,brain,cohort studies,dementia,england,female,genetic predisposition to disease,genotype,humans,male,wales,vascular dementia,genetics
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Depositing User: Pure Connector
Date Deposited: 09 Dec 2013 14:44
Last Modified: 21 Apr 2020 22:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/44935
DOI: 10.1111/j.1365-2990.2010.01130.x

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