Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology:a study in the MRC-CFAS population neuropathology cohort

Viggars, Andrew P, Wharton, Stephen B, Simpson, Julie E, Matthews, Fiona E, Brayne, Carol, Savva, George M, Garwood, Claire, Drew, David, Shaw, Pamela J and Ince, Paul G (2011) Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology:a study in the MRC-CFAS population neuropathology cohort. Neuroscience Letters, 505 (1). pp. 25-30. ISSN 0304-3940

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Abstract

Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to Alzheimer-type pathology remains poorly defined. We have investigated the BBB in temporal cortex of brain donations from a population-representative sample of 92 participants from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), a longitudinal study with a programme of brain donation. BBB alteration was investigated by immunohistochemistry to albumin and fibrinogen and to the tight junction proteins claudin-5, zonula occludens-1 (ZO-1) and occludin. BBB leakage showed wide population-variation and increased with progression of Alzheimer-type pathology, though with considerable overlap between different levels of Alzheimer-type pathology. This was accompanied by increased mean vascular density, but not by down-regulation of tight junction proteins. ZO-1 and occludin were also expressed in glia. Mechanisms leading to BBB leakage in brain ageing remain to be defined, but the population-variation in BBB changes and its early increase in relationship to Alzheimer-type pathology progression suggest that BBB dysfunction contributes to brain ageing.

Item Type: Article
Additional Information: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Uncontrolled Keywords: aged,aged, 80 and over,aging,albumins,blood-brain barrier,cerebral cortex,claudin-5,claudins,cohort studies,collagen type iv,disease progression,down-regulation,female,fibrinogen,humans,male,membrane proteins,occludin,phosphoproteins,statistics, nonparametric,zonula occludens-1 protein
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Depositing User: Pure Connector
Date Deposited: 09 Dec 2013 15:08
Last Modified: 21 Apr 2020 22:17
URI: https://ueaeprints.uea.ac.uk/id/eprint/44926
DOI: 10.1016/j.neulet.2011.09.049

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