Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA

Pereira, J.H., Ha, S.C. and Kim, S.-H. (2008) Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 64 (3). pp. 175-178. ISSN 1744-3091

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Abstract

The Brn-5 protein plays an important role in the control of cellular development and belongs to a class of transcription factors that usually contain two domains: the POU homeodomain (POU) and the POU-specific domain (POU). Since high-quality crystals suitable for crystallographic studies of the proteins of this class are difficult to obtain, all the known structural information available is for POU and/or POU. This paper describes several critical steps that allowed the production of high-quality crystals of the full-length Brn-5 protein complexed with its cognate DNA.

Item Type: Article
Uncontrolled Keywords: transcription factors,protein-dna crystallization,pou family,brn-5 protein
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 08 Nov 2013 12:54
Last Modified: 21 Apr 2020 22:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/44306
DOI: 10.1107/S1744309108003370

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