Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA

Pereira, J.H., Ha, S.C. and Kim, S.-H. (2008) Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 64 (3). pp. 175-178. ISSN 1744-3091

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Abstract

The Brn-5 protein plays an important role in the control of cellular development and belongs to a class of transcription factors that usually contain two domains: the POU homeodomain (POU) and the POU-specific domain (POU). Since high-quality crystals suitable for crystallographic studies of the proteins of this class are difficult to obtain, all the known structural information available is for POU and/or POU. This paper describes several critical steps that allowed the production of high-quality crystals of the full-length Brn-5 protein complexed with its cognate DNA.

Item Type:	Article
Uncontrolled Keywords:	transcription factors,protein-dna crystallization,pou family,brn-5 protein
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	Pure Connector
Date Deposited:	08 Nov 2013 12:54
Last Modified:	24 Oct 2022 04:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/44306
DOI:	10.1107/S1744309108003370

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