The activation of fibroblast growth factors by heparin: Synthesis and structural study of rationally modified heparin-like oligosaccharides

Ojeda, Rafael, Angulo, Jesús ORCID: https://orcid.org/0000-0001-7250-5639, Nieto, Pedro M. and Martín-Lomas, Manuel (2002) The activation of fibroblast growth factors by heparin: Synthesis and structural study of rationally modified heparin-like oligosaccharides. Canadian Journal of Chemistry (CJC), 80 (8). pp. 917-936. ISSN 0008-4042

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Abstract

Heparin-like hexasaccharide 3 and octasaccharide 4 have been synthesized using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy. Both oligosaccharides contain the basic structural motif of the regular region of heparin but have been constructed as to display negatively charged sulfate groups only on one side of their solution helical structures. This charge distribution along the saccharide chain has been designed to get insight into the proposed mechanism for fibroblast growth factors (FGFs) activation that involves heparin-induced FGF dimerization.

Item Type:	Article
Uncontrolled Keywords:	heparin oligosaccharides,synthesis design,conformational analysis,fgf activation
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	21 Oct 2013 15:48
Last Modified:	05 Mar 2024 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43774
DOI:	10.1139/v02-023

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