The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators

Martin-Lomas, M, Nieto, P.M, Khiar, N, Garcı́a, S, Flores-Mosquera, M, Poirot, E, Angulo, J ORCID: https://orcid.org/0000-0001-7250-5639 and Muñoz, J.l (2000) The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators. Tetrahedron: Asymmetry, 11 (1). pp. 37-51. ISSN 0957-4166

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Abstract

The preferred solution conformation of the pseudodisaccharides 7–15, containing the structural motifs that have been proposed for the putative inositolphosphoglycan (IPG) mediators of intracellular signalling processes, have been investigated using NMR spectroscopy and molecular mechanics calculations. The results indicate that the different structural motifs (a and ß 1–6 or a and ß 1–4 glucosaminyl-d-myo-inositol; a and ß 1–6 glucosaminyl-d-chiro-inositol) adopt various three-dimensional shapes that may modulate their biological properties.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	21 Oct 2013 19:16
Last Modified:	24 Oct 2022 04:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43769
DOI:	10.1016/S0957-4166(99)00588-1

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