Angulo, Jesús ORCID: https://orcid.org/0000-0001-7250-5639, De Paz, José-luis, Nieto, Pedro M. and Martín-lomas, Manuel
(2001)
Interaction of heparin with Ca2+: A model study with a synthetic heparin-like hexasaccharide.
Israel Journal of Chemistry, 40 (3-4).
pp. 289-299.
ISSN 0021-2148
Abstract
The binding of Ca2+ to synthetic hexasaccharide 1, containing the structural motifs of the regular region of heparin, has been investigated using NMR spectroscopy and molecular modeling. The NMR data of the calcium salt of 1 indicate the existence of specific Ca2+ binding, and molecular modeling results predict three different types of binding sites with different negative potential and preorganized geometry. The presence of Ca2+ does not seem to affect the overall helical structure of hexasaccharide 1, although it seems to have a marked influence on the flexibility of the oligosaccharide backbone.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Pharmacy |
Depositing User: | Pure Connector |
Date Deposited: | 21 Oct 2013 20:18 |
Last Modified: | 24 Oct 2022 04:48 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/43748 |
DOI: | 10.1560/9REV-7CHB-BB93-09UV |
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