Interaction of heparin with Ca2+: A model study with a synthetic heparin-like hexasaccharide

Angulo, Jesús ORCID: https://orcid.org/0000-0001-7250-5639, De Paz, José-Luis, Nieto, Pedro M. and Martín-Lomas, Manuel (2001) Interaction of heparin with Ca2+: A model study with a synthetic heparin-like hexasaccharide. Israel Journal of Chemistry, 40 (3-4). pp. 289-299. ISSN 0021-2148

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Abstract

The binding of Ca2+ to synthetic hexasaccharide 1, containing the structural motifs of the regular region of heparin, has been investigated using NMR spectroscopy and molecular modeling. The NMR data of the calcium salt of 1 indicate the existence of specific Ca2+ binding, and molecular modeling results predict three different types of binding sites with different negative potential and preorganized geometry. The presence of Ca2+ does not seem to affect the overall helical structure of hexasaccharide 1, although it seems to have a marked influence on the flexibility of the oligosaccharide backbone.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	21 Oct 2013 20:18
Last Modified:	24 Sep 2024 10:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43748
DOI:	10.1560/9REV-7CHB-BB93-09UV

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