Interfacing functionalized carbon nanohorns with primary phagocytic cells

Lacotte, Stéphanie, García, Ainara, Décossas, Marion, Al-Jamal, Wafa' T., Li, Shouping, Kostarelos, Kostas, Muller, Sylviane, Prato, Maurizio, Dumortier, Hélène and Bianco, Alberto (2008) Interfacing functionalized carbon nanohorns with primary phagocytic cells. Advanced Materials, 20 (12). pp. 2421-2426. ISSN 0935-9648

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Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017)
Depositing User: Pure Connector
Date Deposited: 05 Oct 2013 00:57
Last Modified: 09 Jan 2024 01:25
DOI: 10.1002/adma.v20:12

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