Functionalized-quantum-dot-liposome hybrids as multimodal nanoparticles for cancer

Al-Jamal, Wafa' T, Al-Jamal, Khuloud T, Bomans, Paul H, Frederik, Peter M and Kostarelos, Kostas (2008) Functionalized-quantum-dot-liposome hybrids as multimodal nanoparticles for cancer. Small, 4 (9). pp. 1406-1415. ISSN 1613-6829

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Abstract

Functionalized-quantum-dot-liposome (f-QD-L) hybrid nanoparticles are engineered by encapsulating poly(ethylene glycol)-coated QD in the internal aqueous phase of different lipid bilayer vesicles. f-QD-L maintain the QD fluorescence characteristics as confirmed by fluorescence spectroscopy, agarose gel electrophoresis, and confocal laser scanning microscopy. Cationic f-QD-L hybrids lead to dramatic improvements in cellular binding and internalization in tumor-cell monolayer cultures. Deeper penetration into three-dimensional multicellular spheroids is obtained for f-QD-L by modifying the lipid bilayer characteristics of the hybrid system. f-QD-L are injected intratumorally into solid tumor models leading to extensive fluorescent staining of tumor cells compared to injections of the f-QD alone. f-QD-L hybrid nanoparticles constitute a versatile tool for very efficient labeling of cells ex vivo and in vivo, particularly when long-term imaging and tracking of cells is sought. Moreover, f-QD-L offer many opportunities for the development of combinatory therapeutic and imaging (theranostic) modalities by incorporating both drug molecules and QD within the different compartments of a single vesicle.

Item Type: Article
Uncontrolled Keywords: animals,quantum dots,spectrometry, fluorescence,antineoplastic agents,particle size,mice,liposomes,nanoparticles,neoplasm transplantation,microscopy, electron, transmission,neoplasms,mice, inbred c57bl,cryoelectron microscopy,cell line,female,surface properties
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 05 Oct 2013 00:56
Last Modified: 24 Jul 2019 18:56
URI: https://ueaeprints.uea.ac.uk/id/eprint/43584
DOI: 10.1002/smll.200701043

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