Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin D and prostate cancer risk

Bonilla, Carolina, Gilbert, Rebecca, Kemp, John P, Timpson, Nicholas J, Evans, David M, Donovan, Jenny L, Hamdy, Freddie C, Neal, David E, Fraser, William D, Davey Smith, George, Lewis, Sarah J, Lathrop, Mark and Martin, Richard M (2013) Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin D and prostate cancer risk. Cancer Epidemiology, Biomarkers & Prevention, 22 (4). pp. 597-606. ISSN 1538-7755

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Abstract

Ecological and epidemiological studies have identified an inverse association of intensity and duration of sunlight exposure with prostate cancer, which may be explained by a reduction in vitamin D synthesis. Pigmentation traits influence sun exposure and therefore may affect prostate cancer risk. Because observational studies are vulnerable to confounding and measurement error, we used Mendelian randomization to examine the relationship of sun exposure with both prostate cancer risk and the intermediate phenotype, plasma levels of vitamin D.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 25 Sep 2013 01:01
Last Modified: 21 Apr 2020 21:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/43451
DOI: 10.1158/1055-9965.EPI-12-1248

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