Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men

Gregson, Celia L., Tobias, Jon H., Paggiosi, Margaret A., McCloskey, Eugene, Crabtree, Nicola, Steel, Sue A., Duncan, Emma L., Fan, Bo, Shepherd, John A, Fraser, William D. and Smith, George Davey (2013) Analysis of body composition in individuals with high bone mass reveals a marked increase in fat mass in women but not men. The Journal of Clinical Endocrinology and Metabolism, 98 (2). pp. 818-828. ISSN 0021-972X

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Abstract

Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. Atotal of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Amongwomen, fat mass was inversely related to age in controls (P

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 24 Sep 2013 01:00
Last Modified: 14 May 2020 23:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/43420
DOI: 10.1210/jc.2012-3342

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