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ToolsWood, Adrian D., Secombes, Karen R., Thies, Frank, Aucott, Lorna, Black, Alison J., Mavroeidi, Alexandra, Simpson, William G., Fraser, William D., Reid, David M. and Macdonald, Helen M. (2012) Vitamin D supplementation has no effect on conventional cardiovascular risk factors:A parallel-group, double-blind, placebo-controlled RCT. The Journal of Clinical Endocrinology and Metabolism, 97 (10). pp. 3557-3567. ISSN 0021-972X
Full text not available from this repository. (Request a copy)Abstract
Context: Observational studies show an association between low vitamin D status assessed by circulating 25-hydroxyvitamin D and cardiovascular events and mortality. Data from randomized controlled trials are limited. Objective: The aim of this study was to test whether daily doses of vitamin D at 400 or 1000 IU/d for 1 yr affected conventional markers of cardiovascular disease (CVD) risk. Design: We conducted a parallel-group, double-blind, placebo-controlled randomized controlled trial. Randomization was computer generated. Participants and study investigators were blinded to intervention groupings throughout the trial. Setting: The study was conducted at the Clinical Research Facility, University of Aberdeen, United Kingdom. Participants: Atotal of 305 healthy postmenopausal women aged 60-70 yr were recruited for the study. Intervention: Each woman received a daily capsule of 400 or 1000 IU vitamin D3 or placebo randomly allocated. Main Outcome Measures: Primary outcomes were serum lipid profile [total, high-density lipoprotein, and low-density lipoprotein cholesterol; triglycerides; and apolipoproteins A-1 and B ], insulin resistance (homeostatic model assessment), inflammatory biomarkers (high-sensitivity C-reactive protein, IL-6, soluble intracellular adhesion molecule-1), and blood pressure. Results: Atotal of 265 (87%) participants completed all study visits. Small differences between groups for serum apolipoprotein B change [repeated measures ANOVA, P = 0.04; mean (SD), -1.0 (10.0) mg/dl (400 IU); -1.0 (10.0) mg/dl (1000 IU); and +0.02 (10.0) mg/dl (placebo)] were not considered clinically significant. Other systemic markers for CVD risk remained unchanged. There was significant seasonal variation in systolic and diastolic blood pressure independent of vitamin D dose (P
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aged,biological markers,cardiovascular diseases,cholecalciferol,double-blind method,female,humans,middle aged,placebos,postmenopause,risk factors,risk reduction behavior,vitamins,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Sep 2013 01:00 |
| Last Modified: | 19 Oct 2023 01:10 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/43419 |
| DOI: | 10.1210/jc.2012-2126 |
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