Inhibition of electrical activity in mouse pancreatic beta- cells by the Atp/Adp translocase inhibitor, Bongkrekic Acid

Kiranadi, B., Bangham, J. A. and Smith, P. A. (1991) Inhibition of electrical activity in mouse pancreatic beta- cells by the Atp/Adp translocase inhibitor, Bongkrekic Acid. FEBS Letters, 283 (1). pp. 93-96. ISSN 0014-5793

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Abstract

Bongkrekic acid causes fatal food poisoning which is associated with hyperglycaemia. Here we demonstrate that bongkrekic acid, a potent inhibitor of the mitochondrial ATP/ADP translocase, inhibits glucose-induced electrical activity in the pancreatic β-cell through the simulation of ATP-sensitive potassium channel (K-ATP-channel) activity. By comparison of its effects with those of oligomycin, we suggest that bongkrekic acid acts by the inhibition of glucose metabolism and may induce hyperglycaemia by impairing β-cel function.

Item Type: Article
Faculty \ School: Faculty of Science > School of Computing Sciences
Depositing User: Pure Connector
Date Deposited: 06 Nov 2013 13:02
Last Modified: 29 Apr 2022 02:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/42886
DOI: 10.1016/0014-5793(91)80561-G

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