Targeting the oncofetal Thomsen-Friedenreich disaccharide using Jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy

Obaid, Girgis, Chambrier, Isabelle, Cook, Michael J. and Russell, David A. (2012) Targeting the oncofetal Thomsen-Friedenreich disaccharide using Jacalin-PEG phthalocyanine gold nanoparticles for photodynamic cancer therapy. Angewandte Chemie International Edition, 51 (25). pp. 6158-6162. ISSN 1521-3773

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Abstract

Light-sensitive: Targeted photodynamic therapy is achieved by using gold nanoparticles that are stabilized by a mixed monolayer of a hydrophobic zinc phthalocyanine photosensitizer, which produces cytotoxic singlet oxygen, and a water-soluble thiol-functionalized poly(ethylene glycol) carrying the lectin jacalin, which targets the Thomsen–Friedenreich disaccharide antigen at the surface of cancer cells.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017)
Depositing User: Users 2731 not found.
Date Deposited: 29 Oct 2012 16:06
Last Modified: 10 Nov 2022 12:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/40006
DOI: 10.1002/anie.201201468

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