Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ

Wright, Joseph A. ORCID: https://orcid.org/0000-0001-9603-1001, Yu, Jiangang and Spencer, Jonathan B. (2001) Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ. Tetrahedron Letters, 42 (24). pp. 4033-4036.

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Abstract

The selective cleavage of the PMB (4-methoxybenzyl) group in the presence of the NAP (2-naphthylmethyl) group was achieved using CAN with a range of mono-saccharides. The NAP group can then be removed selectively in the presence of a benzyl group using DDQ. This provides a strategy for sequential deprotection of hydroxyl groups.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry
Depositing User:	Users 2731 not found.
Date Deposited:	17 Oct 2012 08:47
Last Modified:	15 Dec 2022 01:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/39938
DOI:	10.1016/S0040-4039(01)00563-9

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