Biogenesis of Y RNA-derived small RNAs is independent of the microRNA pathway

Nicolas Molina, Francisco, Hall, Adam E., Csorba, Tibor, Turnbull, Carly and Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429 (2012) Biogenesis of Y RNA-derived small RNAs is independent of the microRNA pathway. FEBS Letters, 586 (8). pp. 1226-1230. ISSN 1873-3468

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Abstract

Y RNAs are approximately 100 nucleotide long conserved cytoplasmic non-coding RNAs, which produce smaller RNA fragments during apoptosis. Here we show that these smaller RNA molecules are also produced in non-stressed cells and in a range of human cancerous and non-cancerous cell types. Recent reports have speculated that the cleavage products of Y RNAs enter the microRNA pathway. We tested this hypothesis and found that Y5 and Y3 RNA fragments are Dicer independent, they are in different complexes than microRNAs and that they are not co-immunoprecipitated with Ago2. Therefore we conclude that Y RNA fragments do not enter the microRNA pathway.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
Depositing User:	Users 2731 not found.
Date Deposited:	15 Oct 2012 11:06
Last Modified:	08 Nov 2022 11:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/39846
DOI:	10.1016/j.febslet.2012.03.026

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