DNase1: No association with Crohn's disease in a New Zealand population

Morgan, Angharad R., Lam, Wen-Jiun, Han, Dug-Yeo, Fraser, Alan G. and Ferguson, Lynnette R. (2012) DNase1: No association with Crohn's disease in a New Zealand population. ISRN Gastroenterology, 2012. ISSN 2090-4401

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Abstract

DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. The lack of association indicates that DNase1 does not play a significant role in predisposing to CD in the New Zealand population.

Item Type:	Article
Additional Information:	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Users 2731 not found.
Date Deposited:	03 Oct 2012 11:23
Last Modified:	08 Nov 2022 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/39758
DOI:	10.5402/2012/826323

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