Metabolic reprogramming of periwinkle plant culture

Runguphan, Weerawat and O'Connor, Sarah E. (2009) Metabolic reprogramming of periwinkle plant culture. Nature Chemical Biology, 5 (3). pp. 151-153. ISSN 1552-4450

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We transformed an alkaloid biosynthetic gene with reengineered substrate specificity into Catharanthus roseus. The resulting transgenic plant cell culture produced a variety of unnatural alkaloid compounds when cocultured with simple, achiral, commercially available precursors that the reengineered enzyme was designed to accept. This work demonstrates the power of genetic engineering to retailor the structures of complex alkaloid natural products in plant culture.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Depositing User: Rhiannon Harvey
Date Deposited: 21 Mar 2012 15:03
Last Modified: 11 Mar 2024 00:47
DOI: 10.1038/nchembio.141

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