Opportunities for enzyme engineering in natural product biosynthesis

Bernhardt, Peter and O'Connor, Sarah (2009) Opportunities for enzyme engineering in natural product biosynthesis. Current Opinion in Chemical Biology, 13 (1). pp. 35-42. ISSN 1879-0402

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Abstract

Organisms from all kingdoms of life produce a plethora of natural products that display a range of biological activities. One key limitation of developing these natural products into pharmaceuticals is the inability to perform effective, fast, and inexpensive structure–activity relationship studies (SAR). Recently, enzyme engineering strategies have allowed the exploration of metabolic engineering of biosynthetic pathways to create new ‘natural’ products that can be used for SAR. The enzymes that enable the biosynthesis of natural products represent a largely untapped resource of potential biocatalysts. A challenge for the field is how to harness the wealth of reaction types used for natural product metabolism to obtain useful biocatalysts for industrial biotransformations.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Related URLs:
Depositing User: Rhiannon Harvey
Date Deposited: 21 Mar 2012 15:00
Last Modified: 21 Apr 2020 17:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/38411
DOI: 10.1016/j.cbpa.2009.01.005

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