Cheng, Johnathan Z., Coyle, Christine M., Panaccione, Daniel G. and O'Connor, Sarah (2010) A Role for Old Yellow Enzyme in Ergot Alkaloid Biosynthesis. Journal of the American Chemical Society, 132 (6). pp. 1776-1777. ISSN 0002-7863
Full text not available from this repository. (Request a copy)Abstract
Ergot alkaloids, secondary metabolites produced by filamentous fungi, elicit a diverse array of pharmacological effects. The biosynthesis of this class of natural products has not been fully elucidated. Here we demonstrate that a homologue of Old Yellow Enzyme encoded in the Aspergillus fumigatus ergot gene cluster catalyzes reduction of the alpha,beta unsaturated alkene of chanoclavine-I aldehyde 3. This reduction, which yields dihydrochanoclavine aldehyde, facilitates an intramolecular reaction between a secondary amine and aldehyde to form the D ring of the ergot alkaloid structural framework.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Chemistry |
Depositing User: | Rhiannon Harvey |
Date Deposited: | 21 Mar 2012 14:01 |
Last Modified: | 23 Oct 2022 01:23 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/38404 |
DOI: | 10.1021/ja910193p |
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