Mild Reaction Conditions for the Terminal Deuteration of Alkynes

Bew, Sean P. ORCID: https://orcid.org/0000-0002-9087-9463, Hiatt-Gipson, Glyn D., Lovell, Jenny A. and Poullain, Christophe (2012) Mild Reaction Conditions for the Terminal Deuteration of Alkynes. Organic Letters, 14 (2). pp. 456-459. ISSN 1523-7060

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Abstract

Routinely employed syntheses of terminally deuterated alkynes often utilize strong bases (i.e., LDA, n-BuLi, or Grignard reagents) or low (i.e., -78 °C) or elevated (i.e., 56 °C) reaction temperatures; furthermore many of these procedures afford average yields and in some cases less than optimum deuterium incorporation. Herein we report the application of alternative extremely mild reaction conditions that readily afford quantitative yields of terminally deuterated alkynes in a matter of minutes with exceptional isotope incorporation at ambient temperature. © 2012 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
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Date Deposited: 13 Mar 2012 14:29
Last Modified: 24 Sep 2024 08:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/38175
DOI: 10.1021/ol2029178

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