The Influence of Reduced Susceptibility to Fluoroquinolones in Salmonella enterica Serovar Typhi on the Clinical Response to Ofloxacin Therapy

Parry, Christopher M., Vinh, Ha, Chinh, Nguyen Tran, Wain, John, Campbell, James I., Hien, Tran Tinh, Farrar, Jeremy J. and Baker, Stephen (2011) The Influence of Reduced Susceptibility to Fluoroquinolones in Salmonella enterica Serovar Typhi on the Clinical Response to Ofloxacin Therapy. PLoS Neglected Tropical Diseases, 5 (6). ISSN 1935-2735

Full text not available from this repository. (Request a copy)

Abstract

Background: Infection with Salmonella enterica serovar Typhi (S. Typhi) with reduced susceptibility to fluoroquinolones has been associated with fluoroquinolone treatment failure. We studied the relationship between ofloxacin treatment response and the ofloxacin minimum inhibitory concentration (MIC) of the infecting isolate. Individual patient data from seven randomised controlled trials of antimicrobial treatment in enteric fever conducted in Vietnam in which ofloxacin was used in at least one of the treatment arms was studied. Data from 540 patients randomised to ofloxacin treatment was analysed to identify an MIC of the infecting organism associated with treatment failure. Principal Findings: The proportion of patients failing ofloxacin treatment was significantly higher in patients infected with S. Typhi isolates with an MIC=0.25 µg/mL compared with those infections with an MIC of =0.125 µg/mL (p

Item Type: Article
Additional Information: © 2011 Parry et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Rhiannon Harvey
Date Deposited: 22 Feb 2012 13:31
Last Modified: 21 Apr 2020 16:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/37370
DOI: 10.1371/journal.pntd.0001163

Actions (login required)

View Item View Item