Interfamily transfer of a plant pattern-recognition receptor confers broad-spectrum bacterial resistance

Lacombe, Séverine, Rougon-Cardoso, Alejandra, Sherwood, Emma, Peeters, Nemo, Dahlbeck, Douglas, van Esse, H Peter, Smoker, Matthew, Rallapalli, Ghanasyam, Thomma, Bart P H J, Staskawicz, Brian, Jones, Jonathan D G and Zipfel, Cyril (2010) Interfamily transfer of a plant pattern-recognition receptor confers broad-spectrum bacterial resistance. Nature Biotechnology, 28 (4). pp. 365-369. ISSN 1546-1696

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Abstract

Plant diseases cause massive losses in agriculture. Increasing the natural defenses of plants may reduce the impact of phytopathogens on agricultural productivity. Pattern-recognition receptors (PRRs) detect microbes by recognizing conserved pathogen-associated molecular patterns (PAMPs). Although the overall importance of PAMP-triggered immunity for plant defense is established, it has not been used to confer disease resistance in crops. We report that activity of a PRR is retained after its transfer between two plant families. Expression of EFR (ref. 4), a PRR from the cruciferous plant Arabidopsis thaliana, confers responsiveness to bacterial elongation factor Tu in the solanaceous plants Nicotiana benthamiana and tomato (Solanum lycopersicum), making them more resistant to a range of phytopathogenic bacteria from different genera. Our results in controlled laboratory conditions suggest that heterologous expression of PAMP recognition systems could be used to engineer broad-spectrum disease resistance to important bacterial pathogens, potentially enabling more durable and sustainable resistance in the field.

Item Type: Article
Uncontrolled Keywords: bacterial physiological phenomena,immunity, innate,plant diseases,plants, genetically modified,receptors, pattern recognition
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: Users 2731 not found.
Date Deposited: 21 Feb 2012 16:20
Last Modified: 21 Apr 2020 17:14
URI: https://ueaeprints.uea.ac.uk/id/eprint/37340
DOI: 10.1038/nbt.1613

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